Journal article
White matter microstructure is associated with language in children born very preterm
IM Mürner-Lavanchy, CE Kelly, N Reidy, LW Doyle, KJ Lee, T Inder, DK Thompson, AT Morgan, PJ Anderson
Neuroimage Clinical | ELSEVIER SCI LTD | Published : 2018
Abstract
Very preterm birth is associated with altered white matter microstructure and language difficulties, which may compromise communication, social function and academic achievement, but the relationship between these two factors is unclear. The aim of this study was to explore associations between white matter microstructure and language domains of semantics, grammar and phonological awareness at 7-years of age on a whole-brain level and within the arcuate fasciculus, an important language pathway, in very preterm and term-born children. Language was assessed in 145 very preterm-born (<30 weeks’ gestation and/or <1250 g birth weight) and 33 term-born children aged 7 years. Fractional anisotropy..
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Awarded by National Institutes of Health
Funding Acknowledgements
Contract grant sponsor: National Institutes of Health (NIH); Contract grant numbers: R01 HD05709801, P30 HD062171, and UL1 TR000448 to T.E.I.; Contract grant sponsor: The National Health and Medical Research Council (NHMRC) of Australia; Contract grant number: Project Grant No. 237117 to T.E.I. and L.W.D.; Project Grant No. 491209 to P.J.A., T.E.I. and L.W.D.; Project Grant No. 607315 and 1105008 to A.T.M. Contract grant sponsor: The NHMRC of Australia Centre of Research Excellence; Contract grant number: No. 1060733 to L.W.D., P.J.A, J.L.Y.C. and D.K.T.; Contract grant sponsor: The NHMRC of Australia Senior Research Fellowship; Contract grant number: No. 1081288 to P.J.A. Contract grant sponsor: The NHMRC of Australia Career Development Fellowship; Contract grant number: No. 1085754 to D.K.T.; Contract grant number: No. 1053609 to K.J.L. Contract grant sponsor: The NHMRC of Australia Early Career Fellowship; Contract grant numbers: No. 1012236 to D.K.T. and 1053787 to J.L.Y.C; Contract grant sponsor: the United Cerebral Palsy Foundation, The United States to T.E.I.