Journal article

Cu-II(atsm) Attenuates Neuroinflammation

Xin Yi Choo, Jeffrey R Liddell, Mikko T Huuskonen, Alexandra Grubman, Diane Moujalled, Jessica Roberts, Kai Kysenius, Lauren Patten, Hazel Quek, Lotta E Oikari, Clare Duncan, Simon A James, Lachlan E McInnes, David J Hayne, Paul S Donnelly, Eveliina Pollari, Suvi Vahatalo, Katarina Lejavova, Mikko Kettunen, Tarja Malm Show all

FRONTIERS IN NEUROSCIENCE | FRONTIERS MEDIA SA | Published : 2018

Abstract

Background: Neuroinflammation and biometal dyshomeostasis are key pathological features of several neurodegenerative diseases, including Alzheimer's disease (AD). Inflammation and biometals are linked at the molecular level through regulation of metal buffering proteins such as the metallothioneins. Even though the molecular connections between metals and inflammation have been demonstrated, little information exists on the effect of copper modulation on brain inflammation. Methods: We demonstrate the immunomodulatory potential of the copper bis(thiosemicarbazone) complex CuII(atsm) in an neuroinflammatory model in vivo and describe its anti-inflammatory effects on microglia and astrocytes i..

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Grants

Funding Acknowledgements

This study was supported by the Academy of Finland, Sigrid Juselius Foundation and Tekes: Finnish Funding Agency for the Innovation. AW was supported by an Australian National Health and Medical Research Council Senior Research Fellowship. AG was supported by a Melbourne Neuroscience Institute Fellowship, a Melbourne University Early Career Grant, and NHMRC-ARC Dementia Research Development Fellowship. XC was supported by a Henry and Rachael Ackman Travelling Scholarships from The University of Melbourne. JL was supported by an Australian National Health and Medical Research Council Peter Doherty Fellowship. MH was supported by Kuopio University Foundation at the University of Eastern Finland. Part of this work was conducted at the XFM beamline of the Australian Synchrotron, and supported by the Multi-modal Australian ScienceS Imaging and Visualisation Environment (MASSIVE) (www.massive.org.au).