Longitudinal Cognitive Performance in Individuals at Ultrahigh Risk for Psychosis: A 10-year Follow-up

K Allott; SJ Wood; HP Yuen; AR Yung; B Nelson; WJ Brewer; D Spiliotacopoulos; A Bruxner; M Simmons; C Broussard; S Mallawaarachchi; C Pantelis; PD McGorry; A Lin

Conference Proceedings

Longitudinal Cognitive Performance in Individuals at Ultrahigh Risk for Psychosis: A 10-year Follow-up

K Allott, SJ Wood, HP Yuen, AR Yung, B Nelson, WJ Brewer, D Spiliotacopoulos, A Bruxner, M Simmons, C Broussard, S Mallawaarachchi, C Pantelis, PD McGorry, A Lin

Schizophrenia Bulletin | Published : 2019

DOI: 10.1093/schbul/sby143

Abstract

It remains unclear whether the onset of psychosis is associated with deterioration in cognitive performance. The aim of this study was to examine the course of cognitive performance in an ultrahigh risk (UHR) cohort, and whether change in cognition is associated with transition to psychosis and change in functioning. Consecutive admissions to Personal Assessment and Crisis Evaluation (PACE) Clinic between May 1994 and July 2000 who had completed a comprehensive cognitive assessment at baseline and follow-up were eligible (N = 80). Follow-up ranged from 7.3 to 13.4 years (M = 10.4 years; SD = 1.5). In the whole sample, significant improvements were observed on the Similarities (P =. 03), Info..

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University of Melbourne Researchers

Kelly Allott Author

Stephen Wood Author

Hok Yuen Author

Barnaby Nelson Author

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Grants

Awarded by National Alliance for Research on Schizophrenia and Depression

Funding Acknowledgements

This project was supported by National Health and Medical Research Council (NHMRC) Program Grants (350241, 566529) and the Colonial Foundation. Dr Allott is supported by a Ronald Phillip Griffiths Fellowship from the Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne and a NHMRC Career Development Fellowship (1141207). Prof Wood and A/Prof Brewer have been supported by NHMRC Career Development Awards. Prof Nelson was supported by an NHMRC Senior Research Fellowship and a National Alliance for Research on Schizophrenia and Depression (NARSAD) Independent Investigator Award. Prof Pantelis and Prof Yung are the recipients of NHMRC Senior Principal and Senior Research Fellowships, respectively. Prof Yung is also the recipient of a National Institute for Health Research Senior Investigator award. Dr Lin is supported by an NHMRC Career Development Fellowship (1148793).