CD8( ) T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver

Lauren E Holz; Julia E Prier; David Freestone; Thiago M Steiner; Kieran English; Darryl N Johnson; Vanessa Mollard; Anton Cozijnsen; Gayle M Davey; Dale Godfrey; Katsuyuki Yui; Laura K Mackay; Mireille H Lahoud; Irina Caminschi; Geoffrey McFadden; Patrick Bertolino; Daniel Fernandez-Ruiz; William R Heath

Journal article

CD8( ) T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver

Lauren E Holz, Julia E Prier, David Freestone, Thiago M Steiner, Kieran English, Darryl N Johnson, Vanessa Mollard, Anton Cozijnsen, Gayle M Davey, Dale Godfrey, Katsuyuki Yui, Laura K Mackay, Mireille H Lahoud, Irina Caminschi, Geoffrey McFadden, Patrick Bertolino, Daniel Fernandez-Ruiz, William R Heath

Cell Reports | CELL PRESS | Published : 2018

DOI: 10.1016/j.celrep.2018.08.094

University of Melbourne Researchers

Dale Godfrey Author Microbiology and Immunology

Daniel Fernandez Ruiz Author Microbiology and Immunology

David Freestone Author Microbiology and Immunology

Geoffrey McFadden Author Biosciences

Anton Cozijnsen Author Biosciences

Related Projects (4)

IMMUNITY TO INTRACELLULAR INFECTIONS

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IDENTIFYING AND TARGETING DISTINCT POPULATIONS OF RESIDENT MEMORY T CELLS

We have identified a population of immune cells called ‘resident memory T cells’ that reside in tissues of the body. These resident memory T..

ANTIGEN PRESENTATION, RECOGNITION AND THE IMMUNE RESPONSE

This program focuses on understanding the development of immunity during infection or inflammatory diseases using a broad array of technique..

UNCONVENTIONAL T CELLS IN HEALTH AND DISEASE

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Grants

Awarded by NHMRC program grant

Awarded by NHMRC fellowship

Awarded by NHMRC Senior Principal Research Fellowship

Awarded by NHMRC

Funding Acknowledgements

We thank the BRF facility at the Peter Doherty Institute and the Centenary Institute Animal Facility and Advanced Cytometry Facility for technical support. We also thank Dr. John Cambier for providing the Sting knockout mice. L.E.H., D.N.J., and D.I.G. were supported by the Australian Research Council (Centre for Advanced Molecular Imaging). J.E.P., D.F., and L.K.M. were supported by an NHMRC program grant (APP1129711). D.F.-R., T.M.S., and G.D. were supported by an NHMRC program grant (APP1113293). W.R.H. was supported by an NHMRC fellowship (APP1059861). D.I.G. was supported by an NHMRC Senior Principal Research Fellowship (APP1117766). K.E. and P.B. were supported by NHMRC (project grants APP1108565 and APP1086451). G.I.M. was supported by an NHMRC project grant and an ARC Discovery Project and Laureate Fellowship.