Cortical biometals: Changed levels in suicide and with mood disorders

Brian Dean; Linh Q Lam; Elizabeth Scarr; James A Duce

Journal article

Cortical biometals: Changed levels in suicide and with mood disorders

Brian Dean, Linh Q Lam, Elizabeth Scarr, James A Duce

JOURNAL OF AFFECTIVE DISORDERS | ELSEVIER | Published : 2019

DOI: 10.1016/j.jad.2018.09.026

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Abstract

BACKGROUND: Changes in levels of metals have been suggested to contribute to the pathophysiologies of several neurodegenerative disorders but to our knowledge this is the first metallomic study in CNS from patients with mood disorders. The focus of this study was on cortical regions affected by the pathophysiologies of bipolar disorders and major depressive disorders. METHODS: Levels of metals were measured using inductively coupled plasma mass spectrometry in Brodmann's areas (BA) 6, 10 and 17 from patients with major depressive disorders (n = 13), bipolar disorders (n = 12) and age / sex matched controls (n = 13). RESULTS: There were lower levels of cortical strontium (BA 6 & 10), rutheniu..

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University of Melbourne Researchers

Brian Dean Author Florey Department of Neuroscience and Mental Health

James Duce Author Florey Department of Neuroscience and Mental Health

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (grant numbers 1025774, 566967, 1002240), the CRC for Mental Health, One in Five and the Andrew and Claire Heenan Ride for Ben as well as Operational Infrastructure Support from the Victorian State Government.