Journal article
Personalizing survival predictions in advanced colorectal cancer: The ARCAD nomogram project
KM Sjoquist, LA Renfro, RJ Simes, NC Tebbutt, S Clarke, MT Seymour, R Adams, TS Maughan, L Saltz, RM Goldberg, HJ Schmoll, E Van Cutsem, JY Douillard, PM Hoff, JR Hecht, C Tournigand, CJA Punt, M Koopman, H Hurwitz, V Heinemann Show all
Journal of the National Cancer Institute | OXFORD UNIV PRESS INC | Published : 2018
DOI: 10.1093/jnci/djx253
Abstract
Background: Estimating prognosis on the basis of clinicopathologic factors can inform clinical practice and improve risk stratification for clinical trials. We constructed prognostic nomograms for one-year overall survival and six-month progression-free survival in metastatic colorectal carcinoma by using the ARCAD database. Methods: Data from 22 674 patients in 26 randomized phase III clinical trials since 1997 were used to construct and validate Cox models, stratified by treatment arm within each study. Candidate variables included baseline age, sex, body mass index, performance status, colon vs rectal cancer, prior chemotherapy, number and location of metastatic sites, tumor mutation stat..
View full abstractGrants
Awarded by National Institutes of Health
Funding Acknowledgements
ARCAD Foundation grant. This work was supported by the National Institutes of Health (CTSA Grant Number KL2 TR000136 from the National Center for Advancing Translational Science [NCATS]). This work was supported in part by National Health and Medical Research Council (NHMRC) Program grant 1037786.