Journal article

Neprilysin Inhibitors and Bradykinin

Duncan J Campbell

FRONTIERS IN MEDICINE | FRONTIERS MEDIA SA | Published : 2018

Abstract

Bradykinin has important physiological actions related to the regulation of blood vessel tone and renal function, and protection from ischemia reperfusion injury. However, bradykinin also contributes to pathological states such as angioedema and inflammation. Bradykinin is metabolized by many different peptidases that play a major role in the control of bradykinin levels. Peptidase inhibitor therapies such as angiotensin converting enzyme (ACE) and neprilysin inhibitors increase bradykinin levels, and the challenge for such therapies is to achieve the beneficial cardiovascular and renal effects without the adverse consequences such as angioedema that may result from increased bradykinin leve..

View full abstract

Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by National Heart Foundation of Australia


Funding Acknowledgements

This work was funded in part by the National Health and Medical Research Council of Australia (GNT0395508, GNT156723, GNT960229), and the National Heart Foundation of Australia (CR 02M 0829). St Vincent's Institute of Medical Research is supported in part by the Victorian Government's Operational Infrastructure Support Program.