Conference Proceedings

Response of the trilaminar retinal vessel network to intraocular pressure elevation in rat eyes

Bang V Bui, Da Zhao, Lin Wang, Brad Fortune, Zheng He

Investigative Ophthalmology & Visual Science | Association for Research in Vision and Ophthalmology | Published : 2018


Purpose : It is known that inner retinal blood flow is autoregulated to compensate for changes in ocular perfusion pressure (OPP). However, studies have focused on the superficial vessels. Here we test the hypothesis that the superficial, intermediate and deep retinal vascular plexus show different responses to intraocular pressure (IOP) elevation. Methods : Anesthetized (60:5mg/kg ketamine:xylazine) adult Long Evans rats (n=14) were imaged using optical coherence tomography angiography (OCTA) at baseline (IOP 10mmHg) and in follow up mode to examine the vasculature during IOP elevation (10mmHg steps to 110mmHg, each lasting 3 min). We imaged a 20 x 10-degree field starting at one disc diam..

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