Journal article

Genomic and environmental risk factors for cardiametabolic diseases in Africa: methods used for Phase 1 of the AWI-Gen population cross-sectional study

Stuart A Ali, Cassandra Soo, Godfred Agongo, Marianne Alberts, Lucas Amenga-Etego, Romuald P Boua, Ananyo Choudhury, Nigel J Crowther, Cornelius Depuur, F Xavier Gomez-Olive, Issa Guiraud, Tilahun N Haregu, Scott Hazelhurst, Kathleen Kahn, Christopher Khayeka-Wandabwa, Catherine Kyobutungi, Zane Lombard, Felistas Mashinya, Lisa Micklesfield, Shukri F Mohamed Show all

Global Health Action | TAYLOR & FRANCIS LTD | Published : 2018

Abstract

There is an alarming tide of cardiovascular and metabolic disease (CMD) sweeping across Africa. This may be a result of an increasingly urbanized lifestyle characterized by the growing consumption of processed and calorie-dense food, combined with physical inactivity and more sedentary behaviour. While the link between lifestyle and public health has been extensively studied in Caucasian and African American populations, few studies have been conducted in Africa. This paper describes the detailed methods for Phase 1 of the AWI-Gen study that were used to capture phenotype data and assess the associated risk factors and end points for CMD in persons over the age of 40 years in sub-Saharan Afr..

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Grants

Awarded by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), of the National Institutes of Health (NIH), H3Africa Consortium


Awarded by Department of Science and Technology, South Africa


Awarded by FOGARTY INTERNATIONAL CENTER


Awarded by NATIONAL HUMAN GENOME RESEARCH INSTITUTE


Funding Acknowledgements

The AWI-Gen Collaborative Centre is funded by the National Human Genome Research Institute (NHGRI), Office of the Director (OD), Eunice Kennedy Shriver National Institute Of Child Health & Human Development (NICHD), the National Institute of Environmental Health Sciences (NIEHS), the Office of AIDS research (OAR) and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), of the National Institutes of Health (NIH) under award number U54HG006938 and its supplements, as part of the H3Africa Consortium. Additional funding was leveraged from the Department of Science and Technology, South Africa, award number DST/CON 0056/2014, and from the African Partnership for Chronic Disease Research (APCDR).