mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis
Sally K Martin, Stephen Fitter, Nadia El Khawanky, Randall H Grose, Carl R Walkley, Louise E Purton, Markus A Ruegg, Michael N Hall, Stan Gronthos, Andrew CW Zannettino
SCIENTIFIC REPORTS | NATURE PUBLISHING GROUP | Published : 2018
Skeletal osteoblasts are important regulators of B-lymphopoiesis, serving as a rich source of factors such as CXCL12 and IL-7 which are crucial for B-cell development. Recent studies from our laboratory and others have shown that deletion of Rptor, a unique component of the mTORC1 nutrient-sensing complex, early in the osteoblast lineage development results in defective bone development in mice. In this study, we now demonstrate that mTORC1 signalling in pre-osteoblasts is required for normal B-lymphocyte development in mice. Targeted deletion of Rptor in osterix-expressing pre-osteoblasts (Rptorob-/-) leads to a significant reduction in the number of B-cells in the bone marrow, peripheral b..View full abstract
Awarded by National Health and Medical Research Council of Australia
This work was supported by the National Health and Medical Research Council of Australia (APP1030528) and a Royal Adelaide Hospital Mary Overton Early Career Fellowship (S.K.M.).