Journal article

Electrical stimulation of the piriform cortex for the treatment of epilepsy: A review of the supporting evidence

James C Young, David N Vaughan, Antonio G Paolini, Graeme D Jackson



In this review, we consider how the piriform cortex is engaged in both focal and generalized epilepsy networks and postulate the various neural pathways that can be effectively neuromodulated by stimulation at this site. This highlights the common involvement of the piriform cortex in epilepsy. We address both current and future preclinical studies of deep brain stimulation (DBS) of the piriform cortex, with attention to the critical features of these trials that will enable them to be of greatest utility in informing clinical translation. Although recent DBS trials have utilized thalamic targets, electrical stimulation of the piriform cortex may also be a useful intervention for people with..

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Awarded by National Health and Medical Research Council of Australia (NHMRC)

Funding Acknowledgements

The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant. This study was supported by the National Health and Medical Research Council of Australia (NHMRC Project Grant 1091593). James C Young acknowledges that they have been supported through an Australian Government Research Training Program Scholarship.