Long-term follow-up of ICSI-conceived offspring compared with spontaneously conceived offspring: a systematic review of health outcomes beyond the neonatal period
SR Catford, RI McLachlan, MK O'Bryan, JL Halliday
ANDROLOGY | WILEY | Published : 2018
BACKGROUND: A significant increase in the use of intracytoplasmic sperm injection (ICSI) since its introduction in 1992 has been observed worldwide, including beyond its original intended use for severe male factor infertility. Concerns regarding ICSI include the effects of poor quality spermatozoa on offspring health and future fertility, and of the technique itself. The health and development of ICSI-conceived children beyond early infancy have not been comprehensively assessed. OBJECTIVE: A systematic review of health outcomes of ICSI-conceived offspring beyond the neonatal period compared to spontaneously conceived (SC) offspring. DESIGN: PubMed, OVID Medline/Embase, InformIT, Web of Sci..View full abstract
Awarded by National Health and Medical Research Council
S.C is supported through an Australian Government Research Training Program Scholarship. R.M, M.O, and J.H are supported by the National Health and Medical Research Council as Principal Research Fellows (R.M fellowship number: 1022327, M.O fellowship number: 1058356, and J.H fellowship number: 1021252).