Journal article

Congenital heart defect repair with ADAPT tissue engineered pericardium scaffold: An early-stage health economic model

Vladica M Velickovic, Oleg Borisenko, Mikael Svensson, Tim Spelman, Uwe Siebert

PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2018

Abstract

OBJECTIVE: The objective of this study was to evaluate the cost effectiveness of tissue engineered bovine tissue pericardium scaffold (CardioCel) for the repair of congenital heart defects in comparison with surgery using xenogeneic, autologous, and synthetic patches over a 40-year time horizon from the perspective of the UK National Health Service. METHODS: A six-state Markov state-transition model to model natural history of disease and difference in the interventional effect of surgeries depending on patch type implanted. Patches differed regarding their probability of re-operation due to patch calcification, based on a systematic literature review. Transition probabilities were based on ..

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Grants

Funding Acknowledgements

This research was funded by Admedus Ltd. The funders had no role in study design, data collection and analysis, or preparation of the manuscript. Vladica Velickovic, Oleg Borisenko, Mikael Svensson, and Tim Spelman are/were employees of Synergus AB. Synergus AB provided support in the form of salaries for authors VV, OB, MS and TS, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the 'author contributions' section.