Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding
Franklin L Zhong, Kim Robinson, Daniel Eng Thiam Teo, Kiat-Yi Tan, Chrissie Lim, Cassandra R Harapas, Chien-Hsiung Yu, William H Xie, Radoslaw M Sobota, Veonice Bijin Au, Richard Hopkins, Andrea D'Osualdo, John C Reed, John E Connolly, Seth L Masters, Bruno Reversade
Journal of Biological Chemistry | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | Published : 2018
Awarded by National Medical Research Council MS-CETSA platform Grant
Awarded by National Medical Research Council Young Investigator Grant
Awarded by National Health and Medical Research Council
This work was supported by core funding from the Institute of Molecular and Cell Biology (IMCB) and Institute of Medical Biology (IMB) Strategic Positioning Fund (Biomedical Research Council (BMRC), A*STAR) (to B. R. and R. M. S.), Young Investigator Grant YIG 2015 (BMRC, A*STAR) (to B. R. and R. M. S.), National Medical Research Council MS-CETSA platform Grant MOHIAFCAT2/004/2015 (to B. R. and R. M. S.), National Medical Research Council Young Investigator Grant NMRC/OFYIRG/0046/2017 (to F. L. Z.), National Health and Medical Research Council Grants 1142354 and 1099262 (to S. L. M.), funds from the Sylvia and Charles Viertel Foundation (to S. L. M.), a Howard Hughes Medical Institute-Wellcome International Research Scholarship (to S. L. M.), and funds from GlaxoSmithKline (to S. L. M.). The authors declare that they have no conflicts of interest with the contents of this article.Fellow of the Branco Weiss Foundation. Recipient of the A*STAR Investigatorship and Senior National Research Foundation (NRF) fellowship. EMBO Young Investigator.