Prediction Models of Functional Outcomes for Individuals in the Clinical High-Risk State for Psychosis or with Recent-Onset Depression: A Multimodal, Multisite Machine Learning Analysis

N Koutsouleris; L Kambeitz-Ilankovic; S Ruhrmann; M Rosen; A Ruef; DB Dwyer; M Paolini; K Chisholm; J Kambeitz; T Haidl; A Schmidt; J Gillam; F Schultze-Lutter; P Falkai; M Reiser; A Riecher-Rössler; R Upthegrove; J Hietala; RKR Salokangas; C Pantelis; E Meisenzahl; SJ Wood; D Beque; P Brambilla; S Borgwardt

Journal article

Prediction Models of Functional Outcomes for Individuals in the Clinical High-Risk State for Psychosis or with Recent-Onset Depression: A Multimodal, Multisite Machine Learning Analysis

N Koutsouleris, L Kambeitz-Ilankovic, S Ruhrmann, M Rosen, A Ruef, DB Dwyer, M Paolini, K Chisholm, J Kambeitz, T Haidl, A Schmidt, J Gillam, F Schultze-Lutter, P Falkai, M Reiser, A Riecher-Rössler, R Upthegrove, J Hietala, RKR Salokangas, C Pantelis Show all

JAMA Psychiatry | AMER MEDICAL ASSOC | Published : 2018

DOI: 10.1001/jamapsychiatry.2018.2165

Abstract

Importance: Social and occupational impairments contribute to the burden of psychosis and depression. There is a need for risk stratification tools to inform personalized functional-disability preventive strategies for individuals in at-risk and early phases of these illnesses. Objective: To determine whether predictors associated with social and role functioning can be identified in patients in clinical high-risk (CHR) states for psychosis or with recent-onset depression (ROD) using clinical, imaging-based, and combined machine learning; assess the geographic, transdiagnostic, and prognostic generalizability of machine learning and compare it with human prognostication; and explore sequenti..

View full abstract

University of Melbourne Researchers

Dom Dwyer Author

Christos Pantelis Author

Stephen Wood Author

Related Projects (3)

RESEARCH FELLOWSHIP - PROF CHRISTOS PANTELIS

I have established and head the Melbourne Neuropsychiatry Centre within the University of Melbourne. My university position is a research ch..

PERSONALISED PROGNOSTIC TOOLS FOR EARLY PSYCHOSIS MANAGEMENT (PRONIA)

Psychosis can be a devastating illness with harmful long-term consequences, such as chronic schizophrenia. To avoid distress, deterioration,..

NEUROBIOLOGICAL 'RISK' AND 'RESILIENCE' BIOMARKERS OF SEVERE MENTAL ILLNESS

Mental disorders of childhood (schizotypal disorder, autism spectrum disorders) and adolescence (psychoses, schizophrenia) represent a major..

Grants

Awarded by National Institute of Mental Health

Funding Acknowledgements

PRONIA is a Collaborative Project funded by the European Union under the 7th Framework Programme (grant 602152). Dr Pantelis was supported by National Health and Medical Research Council Senior Principal Research Fellowship (grants 628386 and 1105825) and European Union-National Health and Medical Research Council (grant 1075379).