Journal article
The UK Biobank resource with deep phenotyping and genomic data
C Bycroft, C Freeman, D Petkova, G Band, LT Elliott, K Sharp, A Motyer, D Vukcevic, O Delaneau, J O’Connell, A Cortes, S Welsh, A Young, M Effingham, G McVean, S Leslie, N Allen, P Donnelly, J Marchini
Nature | NATURE PORTFOLIO | Published : 2018
Abstract
The UK Biobank project is a prospective cohort study with deep genetic and phenotypic data collected on approximately 500,000 individuals from across the United Kingdom, aged between 40 and 69 at recruitment. The open resource is unique in its size and scope. A rich variety of phenotypic and health-related information is available on each participant, including biological measurements, lifestyle indicators, biomarkers in blood and urine, and imaging of the body and brain. Follow-up information is provided by linking health and medical records. Genome-wide genotype data have been collected on all participants, providing many opportunities for the discovery of new genetic associations and the ..
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Awarded by Medical Research Council
Funding Acknowledgements
We acknowledge Wellcome Trust Core Awards 090532/Z/09/Z and 203141/Z/16/Z and grants 095552/Z/11/Z (to P.D.), 100956/Z/13/Z (to G.M.) and 100308/Z/12/Z (to A.C.). J.M. is supported by European Research Council grant 617306. S.L. is supported by Australian NHMRC Career Development Fellowship 1053756. The sample processing and genotyping was supported by the National Institute for Health Research, Medical Research Council, and British Heart Foundation. We thank the Research Computing Core at the Wellcome Centre for Human Genetics for assistance with the computational workload. We thank Affymetrix for discussions concerning quality control. We thank A. Young, A. Dilthey and L. Moutsianas for their assistance with aspects of the data analysis. We acknowledge UK Biobank co-ordinating centre staff for their role in extracting the DNA for this project. We thank M. Kuzma-Kuzniarska (http://mybioscience.org/) for Fig. 1.