Journal article

Gene expression profiling of postnatal lung development in the marsupial gray short-tailed opossum (Monodelphis domestica) highlights conserved developmental pathways and specific characteristics during lung organogenesis

Vengamanaidu Modepalli, Amit Kumar, Julie A Sharp, Norman R Saunders, Kevin R Nicholas, Christophe Lefevre

BMC GENOMICS | BMC | Published : 2018

Abstract

BACKGROUND: After a short gestation, marsupials give birth to immature neonates with lungs that are not fully developed and in early life the neonate partially relies on gas exchange through the skin. Therefore, significant lung development occurs after birth in marsupials in contrast to eutherian mammals such as humans and mice where lung development occurs predominantly in the embryo. To explore the mechanisms of marsupial lung development in comparison to eutherians, morphological and gene expression analysis were conducted in the gray short-tailed opossum (Monodelphis domestica). RESULTS: Postnatal lung development of Monodelphis involves three key stages of development: (i) transition f..

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Grants

Awarded by Bill & Melinda Gate Foundation


Funding Acknowledgements

Modepalli. V and Kumar. A were funded by the Deakin University PhD program. Animals were maintained at The University of Melbourne facility. The work was also partially supported by a Grand Challenges Explorations grant from Bill & Melinda Gate Foundation "A new approach to identify proteins that improve gut development and function in premature and low birth weight babies (ID#OPP1045915)" to cover sequencing costs.