Journal article

Fiducial markers: can the urologist do better?

Catriona Duncan, Daryl Lim Joon, Nathan Lawrentschuk, Trish Jenkins, Michal Schneider, Vincent Khoo, Michael Chao, Marita Lawlor, Rachel O'Meara, Colleen Berry, Angela Viotto, Kerryn Brown, Morikatsu Wada, Farshad Foroudi, Shomik Sengupta

WORLD JOURNAL OF UROLOGY | SPRINGER | Published : 2019

Abstract

INTRODUCTION: Radiotherapy to the bladder has a risk of toxicity to pelvic structures, which can be reduced by using fiducial markers for targeting. Injectable contrast offers an alternative marker to gold seeds, which may fall out or exacerbate scarring. Combining contrast agents with tissue glue can minimize dispersion through tissue, enhancing its utility. We evaluated combinations of contrast agents and tissue glue using porcine bladder, for feasibility and utility as fiducial markers to aid image-guided radiotherapy. METHODS: Different contrast agents (Lipiodol ultra or Urografin) were combined with different tissue glues (Histoacryl, Tisseal or Glubran2). The mixtures were endoscopical..

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