Journal article

Insights From Deep Sequencing of the HBV Genome-Unique, Tiny, and Misunderstood

Anna L McNaughton, Valentina D'Arienzo, M Azim Ansari, Sheila F Lumley, Margaret Littlejohn, Peter Revill, Jane A McKeating, Philippa C Matthews

Gastroenterology | W B SAUNDERS CO-ELSEVIER INC | Published : 2019

Abstract

Hepatitis B virus (HBV) is a unique, tiny, partially double-stranded, reverse-transcribing DNA virus with proteins encoded by multiple overlapping reading frames. The substitution rate is surprisingly high for a DNA virus, but lower than that of other reverse transcribing organisms. More than 260 million people worldwide have chronic HBV infection, which causes 0.8 million deaths a year. Because of the high burden of disease, international health agencies have set the goal of eliminating HBV infection by 2030. Nonetheless, the intriguing HBV genome has not been well characterized. We summarize data on the HBV genome structure and replication cycle, explain and quantify diversity within and a..

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Grants

Awarded by Wellcome Trust Intermediate Fellowship


Awarded by NHMRC


Awarded by EU 2020 Research and Innovation Programme


Awarded by Wellcome Trust


Funding Acknowledgements

Philippa C. Matthews is funded by a Wellcome Trust Intermediate Fellowship (grant 110110). Peter Revill's research program is funded in part by the NHMRC (APP1159305). Jane A. McKeating is funded by the EU 2020 Research and Innovation Programme (grant agreement 667273 Hep-CAR consortia) and the Wellcome Trust (IA 200838/Z/16/Z).