Efficacy of Low-Dose Amitriptyline for Chronic LowBack Pain A Randomized Clinical Trial
Donna M Urquhart, Anita E Wluka, Maurits Van Tulder, Stephane Heritier, Andrew Forbes, Chris Fong, Yuanyuan Wang, Malcolm R Sim, Stephen J Gibson, Carolyn Arnold, Flavia M Cicuttini
JAMA INTERNAL MEDICINE | AMER MEDICAL ASSOC | Published : 2018
Importance: Antidepressants at low dose are commonly prescribed for the management of chronic low back pain and their use is recommended in international clinical guidelines. However, there is no evidence for their efficacy. Objective: To examine the efficacy of a low-dose antidepressant compared with an active comparator in reducing pain, disability, and work absence and hindrance in individuals with chronic low back pain. Design, Setting, and Participants: A double-blind, randomized clinical trial with a 6-month follow-up of adults with chronic, nonspecific, low back pain who were recruited through hospital/medical clinics and advertising was carried out. Intervention: Low-dose amitriptyli..View full abstract
Awarded by National Health and Medical Research Council (NHMRC, Australia)
Awarded by NHMRC
This work was supported by the National Health and Medical Research Council (NHMRC, Australia, ID 1024401). Drs Urquhart, Wluka, and Wang are recipients of NHMRC Career Development Fellowships (Clinical Level 1 No. 1011975; Clinical Level 2 No. 1063574; Clinical Level 1 No. 1065464, respectively).