Journal article

Similar neurocognitive outcomes after 48 weeks in HIV-1-infected participants randomized to continue tenofovir/emtricitabine plus atazanavir/ritonavir or simplify to abacavir/lamivudine plus atazanavir

Kevin Robertson, Paul Maruff, Lisa L Ross, David Wohl, Catherine B Small, Howard Edelstein, Mark S Shaefer

Journal of NeuroVirology | SPRINGER | Published : 2019

Abstract

Human immunodeficiency virus (HIV)-associated neurocognitive disorders can persist in many patients despite achieving viral suppression while on antiretroviral therapy (ART). Neurocognitive function over 48 weeks was evaluated using a Cogstate test battery assessing psychomotor function, attention, learning, and working memory in 293 HIV-1-infected, ART-experienced, and virologically suppressed adults. The ASSURE study randomized participants 1:2 to remain on tenofovir/emtricitabine (TDF/FTC) and ritonavir-boosted atazanavir (ATV/r) or simplify to abacavir/lamivudine + atazanavir (ABC/3TC + ATV). Neurocognitive z-scores were computed using demographically adjusted normative data and were cla..

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University of Melbourne Researchers