Two Ventricles Are Not Better Than One in the Fontan Circulation: Equivalent Late Outcomes
Supreet P Marathe, Diana Zannino, William Y Shi, Karin du Plessis, Jascha Kehr, Gopinath Perumal, Jessica Sun, Thomas L Gentles, Julian Ayer, Gary F Sholler, Charlotte E Verrall, Nelson Alphonso, David Andrews, Yves d'Udekem, David S Winlaw
ANNALS OF THORACIC SURGERY | ELSEVIER SCIENCE INC | Published : 2019
BACKGROUND: A subset of patients who underwent Fontan operations has two adequate-sized ventricles, but an anatomic biventricular circulation cannot be achieved because of complex morphology or for technical reasons. This study sought to determine whether these patients with two-ventricle Fontan circulation had superior outcomes compared with those with a single ventricle. METHODS: A binational Fontan Registry of patients (n = 1,377) was analyzed to identify those patients with two adequate ventricles. This cohort was compared with patients with single-ventricle Fontan circulation. The primary end point was a composite end point called "Fontan failure" encompassing death, heart transplantati..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC)
The authors wish to thank their research assistants for their support in maintaining the Australian and New Zealand Fontan Registry and the support provided to the Murdoch Children's Research Institute by the Victorian Government's Operational Infrastructure Support Program. This work was supported in part by the (1) Wishaw Trust, Heart Centre for Children, The Children's Hospital at Westmead and (2) the National Health and Medical Research Council (NHMRC) Partnership grant (1076849). Dr d'Udekem is a Clinician Practitioner Fellow of the NHMRC (1082186).