Journal article

Exploring comorbid depression and physical health trajectories: A case-based computational modelling approach

Brian Castellani, Frances Griffiths, Rajeev Rajaram, Jane Gunn

JOURNAL OF EVALUATION IN CLINICAL PRACTICE | WILEY | Published : 2018

Abstract

While comorbid depression/physical health is a major clinical concern, the conventional methods of medicine make it difficult to model the complexities of this relationship. Such challenges include cataloguing multiple trends, developing multiple complex aetiological explanations, and modelling the collective large-scale dynamics of these trends. Using a case-based complexity approach, this study engaged in a richly described case study to demonstrate the utility of computational modelling for primary care research. N = 259 people were subsampled from the Diamond database, one of the largest primary care depression cohort studies worldwide. A global measure of depressive symptoms (PHQ-9) and..

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