The role of inflammatory markers in assessment of disease activity in systemic sclerosis.
Laura Ross, Wendy Stevens, Candice Rabusa, Michelle Wilson, Nava Ferdowsi, Jennifer Walker, Joanne Sahhar, Gene-Siew Ngian, Jane Zochling, Janet Roddy, Kathleen Tymms, Gabor Major, Gemma Strickland, Susanna M Proudman, Mandana Nikpour
Clin Exp Rheumatol | Published : 2018
OBJECTIVES: The role of the erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) in the assessment of disease activity in systemic sclerosis (SSc) remains controversial. We sought to evaluate the relationship between clinical features of SSc and raised inflammatory markers and to determine if changes in ESR and CRP reflect changes in other disease features over time. METHODS: One thousand, five hundred and forty-five patients enrolled in the Australian Scleroderma Cohort Study were observed over a mean 3.52±2.91 years and assessed at 6,119 study visits. Generalised estimating equations were used to determine the relationship between ESR≥20mm/hr and CRP≥5mg/L and features of dise..View full abstract