SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans
Huan Cao, Ursula Lakner, Bernard de Bono, James A Traherne, John Trowsdale, Alexander D Barrow
EUROPEAN JOURNAL OF IMMUNOLOGY | WILEY | Published : 2008
Sialic acid binding immunoglobulin-like lectins (Siglec) are important components of immune recognition. The organization of Siglec genes in different species is consistent with rapid selection imposed by pathogens. We studied SIGLEC11 genes in human, rodent, dog, cow and non-human primates. The lineages of SIGLEC11 genes in these species have undergone dynamic gene duplication and conversion, forming a potential inhibitory (SIGLEC11)/activating (SIGLEC16) receptor pair in chimpanzee and humans. A cDNA encoding human Siglec-16, currently classed as a pseudogene in the databases (SIGLECP16), is expressed in various cell lines and tissues. A polymorphism screen for the two alleles (wild type a..View full abstract
Awarded by Medical Research Council
We thank Prof. Paul Crocker for helpful suggestions and Wellcome Trust and BBSRC for grant support.