The Capricious Nature of Bacterial Pathogens: Phasevarions and vaccine Development
Aimee Tan, John M Atack, Michael P Jennings, Kate L Seib
Frontiers in Immunology | FRONTIERS MEDIA SA | Published : 2016
Infectious diseases are a leading cause of morbidity and mortality worldwide, and vaccines are one of the most successful and cost-effective tools for disease prevention. One of the key considerations for rational vaccine development is the selection of appropriate antigens. Antigens must induce a protective immune response, and this response should be directed to stably expressed antigens so the target microbe can always be recognized by the immune system. Antigens with variable expression, due to environmental signals or phase variation (i.e., high frequency, random switching of expression), are not ideal vaccine candidates because variable expression could lead to immune evasion. Phase va..View full abstract
Awarded by Australian National Health and Medical Research Council (NHMRC)
This study was funded by Australian National Health and Medical Research Council (NHMRC) (Project Grants 2163530 and Career Development Fellowship to KS; Project Grant 1099279 to KS and JA; Program Grant 1071659 to MJ); Garnett Passe and Rodney Williams Memorial Foundation Research Training Fellowship to AT.