Virulence determinants of Moraxella catarrhalis: distribution and considerations for vaccine development
Luke V Blakeway, Aimee Tan, Ian RA Peak, Kate L Seib
MICROBIOLOGY-SGM | MICROBIOLOGY SOC | Published : 2017
Moraxella catarrhalis is a human-restricted opportunistic bacterial pathogen of the respiratory mucosa. It frequently colonizes the nasopharynx asymptomatically, but is also an important causative agent of otitis media (OM) in children, and plays a significant role in acute exacerbations of chronic obstructive pulmonary disease (COPD) in adults. As the current treatment options for M. catarrhalis infection in OM and exacerbations of COPD are often ineffective, the development of an efficacious vaccine is warranted. However, no vaccine candidates for M. catarrhalis have progressed to clinical trials, and information regarding the distribution of M. catarrhalis virulence factors and vaccine ca..View full abstract
Awarded by Australian National Health and Medical Research Council (NHMRC)
The authors are supported by the Australian National Health and Medical Research Council (NHMRC) (career development fellowship 1045235 and project grant 1099278 to K. L. S.], the Australian Government (APA to L. V. B), the Garnett Passe and the Rodney Williams Memorial Foundation (Fellowship to A. T.).