Tear film inflammatory cytokine upregulation in contact lens discomfort
Anne Gad, Algis Jonas Vingrys, Chinn Yi Wong, David Charles Jackson, Laura Elizabeth Downie
OCULAR SURFACE | ELSEVIER | Published : 2019
PURPOSE: To investigate the ocular inflammatory response, using clinical and immunological techniques, in people experiencing contact lens (CL) discomfort. METHODS: This study involved 38 adults who were full-time, silicone-hydrogel CL wearers. Participants were categorized into groups based upon a validated CL dry-eye questionnaire (CLDEQ-8) (n = 17 'asymptomatic', CLDEQ-8 score 0.05). The I-SOD was greater in symptomatic than asymptomatic CL wearers (23.1 ± 2.6 versus 11.3 ± 1.4 mOsmol/L, p = 0.001). People experiencing CL discomfort had higher tear IL-17A (122.6 ± 23.7 versus 44.0 ± 10.0 pg/mL, p = 0.02) and reduced tear stability (6.3 ± 1.1 versus 10.4 ± 1.6 s, p = 0.03) after several h..View full abstract
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This study was funded by a grant from CooperVision (LED, 2015). The funder did not have any role in the collection, analysis and interpretation of data; writing of the manuscript; or in the decision to submit the article for publication.