Journal article

Glycinergic neurotransmission in the rostral ventrolateral medulla controls the time course of baroreflex-mediated sympathoinhibition

Hong Gao, Willian S Korim, Song T Yao, Cheryl M Heesch, Andrei V Derbenev

JOURNAL OF PHYSIOLOGY-LONDON | WILEY | Published : 2019

Abstract

KEY POINTS: To maintain appropriate blood flow to various tissues of the body under a variety of physiological states, autonomic nervous system reflexes regulate regional sympathetic nerve activity and arterial blood pressure. Our data obtained in anaesthetized rats revealed that glycine released in the rostral ventrolateral medulla (RVLM) plays a critical role in maintaining arterial baroreflex sympathoinhibition. Manipulation of brainstem nuclei with known inputs to the RVLM (nucleus tractus solitarius and caudal VLM) unmasked tonic glycinergic inhibition in the RVLM. Whole-cell, patch clamp recordings demonstrate that both GABA and glycine inhibit RVLM neurons. Potentiation of neurotransm..

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Grants

Awarded by National Institute of Health


Awarded by Australian Research Council Future Fellowship


Awarded by National Health and Medical Research Council of Australia


Awarded by Centre for Neuroanatomy with Neurotropic Viruses


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Funding Acknowledgements

This work was supported by National Institute of Health R01 HL122829 (A. V. Derbenev) and R01 HL098602 (C. M. Heesch); Australian Research Council Future Fellowship FT170100363 and the National Health and Medical Research Council of Australia GNT1079680 (S. T. Yao), High Blood Pressure Research Council of Australia; the Rebecca L Cooper Medical Foundation; and theVictorianGovernment through the Operational Infrastructure Scheme (W. S. Korim). PRV-152 was obtained from the Centre for Neuroanatomy with Neurotropic Viruses (P40 OD10996).