Journal article

The new screening program to prevent cervical cancer using HPV DNA: getting the balance right in maintaining quality

Suzanne M Garland, Wayne Dimech, Peter Collignon, Louise Cooley, Graeme R Nimmo, David W Smith, Rob Baird, William Rawlinson, Anna-Maria Costa, Geoff Higgins

Journal of Pathology: Clinical Research | WILEY | Published : 2018

Abstract

Along with the reduction in human papillomavirus (HPV) infection and cervical abnormalities as a result of the successful HPV vaccination program, Australia is adopting a new screening strategy. This involves a new paradigm moving from cervical cytological screening to molecular nucleic acid technology (NAT), using HPV DNA assays as primary screening methodology for cervical cancer prevention. These assays must strike a balance between sufficient clinical sensitivity to detect or predict high-grade cervical intraepithelial lesions, the precursor to cervical cancer, without being too sensitive and detecting transient infection not destined for disease. Ensuring the highest quality HPV NAT is ..

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