Can GABA turn pancreatic α-cells into β-cells?
Decio L Eizirik, Esteban N Gurzov
Nat Rev Endocrinol | Published : 2018
The neurotransmitter GABA has been shown to induce the transdifferentiation of α-cells into β-cells, restoring normoglycaemia in a mouse model of diabetes mellitus. A recent paper by Amanda Ackermann and colleagues, however, failed to reproduce these findings. Here, we discuss the discrepant findings and propose a systematic approach to solve the controversy.