Expression of miR-206 in human islets and its role in glucokinase regulation.
Mugdha V Joglekar, Wilson KM Wong, Cody-Lee Maynard, Malati R Umrani, David Martin, Thomas Loudovaris, Helen E Thomas, Louise T Dalgaard, Anandwardhan A Hardikar
Am J Physiol Endocrinol Metab | Published : 2018
Inappropriate insulin secretion from β-cells is considered as an early sign of impaired glucose tolerance and type 2 diabetes (T2D). Glucokinase (GCK) is an important enzyme that regulates glucose metabolism and ensures that the normal circulating glucose concentrations are maintained. GCK expression is induced by glucose and regulated via transcription factors and regulatory proteins. Recently, microRNA-206 (miR-206) was reported to regulate GCK and alter glucose tolerance in normal and high-fat diet-fed mice. Although the study findings have implications for human diabetes, studies in human islets are lacking. Here, we analyze human islets from individuals without or with T2D, using TaqMan..View full abstract
Awarded by Danish Diabetes Academy (DDA)