IL-2 Enhances Gut Homing Potential of Human Naive Regulatory T Cells Early in Life
Peter S Hsu, Catherine L Lai, Mingjing Hu, Brigitte Santner-Nanan, Jane E Dahlstrom, Cheng Hiang Lee, Ayesha Ajmal, Amanda Bullman, Susan Arbuckle, Ahmed Al Saedi, Lou Gacis, Reta Nambiar, Andrew Williams, Melanie Wong, Dianne E Campbell, Ralph Nanan
JOURNAL OF IMMUNOLOGY | AMER ASSOC IMMUNOLOGISTS | Published : 2018
Recent evidence suggests early environmental factors are important for gut immune tolerance. Although the role of regulatory T (Treg) cells for gut immune homeostasis is well established, the development and tissue homing characteristics of Treg cells in children have not been studied in detail. In this article, we studied the development and homing characteristics of human peripheral blood Treg cell subsets and potential mechanisms inducing homing molecule expression in healthy children. We found contrasting patterns of circulating Treg cell gut and skin tropism, with abundant β7 integrin+ Treg cells at birth and increasing cutaneous lymphocyte Ag (CLA+) Treg cells later in life. β7 integri..View full abstract
This work was supported by the Nepean Medical Research Foundation, the Allergy and Immunology Foundation of Australasia, and an Early Career Researcher Kickstart grant from The University of Sydney.