Journal article

IL-2 Enhances Gut Homing Potential of Human Naive Regulatory T Cells Early in Life

Peter S Hsu, Catherine L Lai, Mingjing Hu, Brigitte Santner-Nanan, Jane E Dahlstrom, Cheng Hiang Lee, Ayesha Ajmal, Amanda Bullman, Susan Arbuckle, Ahmed Al Saedi, Lou Gacis, Reta Nambiar, Andrew Williams, Melanie Wong, Dianne E Campbell, Ralph Nanan

JOURNAL OF IMMUNOLOGY | AMER ASSOC IMMUNOLOGISTS | Published : 2018

Abstract

Recent evidence suggests early environmental factors are important for gut immune tolerance. Although the role of regulatory T (Treg) cells for gut immune homeostasis is well established, the development and tissue homing characteristics of Treg cells in children have not been studied in detail. In this article, we studied the development and homing characteristics of human peripheral blood Treg cell subsets and potential mechanisms inducing homing molecule expression in healthy children. We found contrasting patterns of circulating Treg cell gut and skin tropism, with abundant β7 integrin+ Treg cells at birth and increasing cutaneous lymphocyte Ag (CLA+) Treg cells later in life. β7 integri..

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University of Melbourne Researchers