Journal article

Validation of a genetic risk score for Arkansas women of color

Athena Starlard-Davenport, Richard Allman, Gillian S Dite, John L Hopper, Erika Spaeth Tuff, Stewart Macleod, Susan Kadlubar, Michael Preston, Ronda Henry-Tillman

PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2018

Abstract

African American women in the state of Arkansas have high breast cancer mortality rates. Breast cancer risk assessment tools developed for African American underestimate breast cancer risk. Combining African American breast cancer associated single-nucleotide polymorphisms (SNPs) into breast cancer risk algorithms may improve individualized estimates of a woman's risk of developing breast cancer and enable improved recommendation of screening and chemoprevention for women at high risk. The goal of this study was to confirm with an independent dataset consisting of Arkansas women of color, whether a genetic risk score derived from common breast cancer susceptibility SNPs can be combined with ..

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Grants

Funding Acknowledgements

A. Starlard-Davenport and R. Henry-Tillman report receiving commercial research support from Genetic Technologies Ltd. who provided support in the form of salaries for author AS-D, but did not have any additional role in the study design, data collection and analysis, or decision to publish. Phenogen Sciences Inc. did not provide any financial support, but did have an additional role in preparation of the manuscript. The specific roles of these authors are articulated in the 'author contributions' section.