Journal article

Nutrient and immune sensing are obligate pathways in metabolism, immunity, and disease

Abishek Iyer, Lindsay Brown, Jonathan P Whitehead, Johannes B Prins, David P Fairlie

FASEB JOURNAL | FEDERATION AMER SOC EXP BIOL | Published : 2015

Abstract

The growth and survival of multicellular organisms depend upon their abilities to acquire and metabolize nutrients, efficiently store and harness energy, and sense and fight infection. Systems for sensing and using nutrients have consequently coevolved alongside systems for sensing and responding to danger signals, including pathogens, and share many of the same cell signaling proteins and networks. Diets rich in carbohydrates and fats can overload these systems, leading to obesity, metabolic dysfunction, impaired immunity, and cardiovascular disease. Excessive nutrient intake promotes adiposity, typically altering adipocyte function and immune cell distribution, both of which trigger metabo..

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University of Melbourne Researchers

Grants

Awarded by Australian National Health and Medical Research Council


Awarded by Australian Research Council (ARC) Grant


Awarded by ARC Federation Fellowship


Awarded by ARC Centre of Excellence in Advanced Molecular Imaging aimed at better understanding the molecular basis of immunity


Funding Acknowledgements

This work was supported by the Australian National Health and Medical Research Council through Grants APP1028423 (to D.P.F. and L.B.) and APP1084083 (to D.P.F., A.I., and J.B.P.), and an SPRF1027369 Fellowship (to D.P.F.); a University of Queensland Postdoctoral Fellowship (to A.I.); a Queensland State Government (Collaboration and Innovation Fund) grant (to D.P.F., J.P.W., and J.B.P.); and Australian Research Council (ARC) Grant DP130100629, ARC Federation Fellowship FF0668733, and the ARC Centre of Excellence in Advanced Molecular Imaging aimed at better understanding the molecular basis of immunity (CE140100011; all to D.P.F.). The authors declare no conflicts of interest.