Journal article

An Inhibitor of Phospholipase A(2) Group IIA Modulates Adipocyte Signaling and Protects Against Diet-Induced Metabolic Syndrome in Rats

Abishek Iyer, Junxian Lim, Hemant Poudyal, Robert C Reid, Jacky Y Suen, Julie Webster, Johannes B Prins, Jonathan P Whitehead, David P Fairlie, Lindsay Brown

Diabetes | AMER DIABETES ASSOC | Published : 2012

Abstract

Obesity, type 2 diabetes, and cardiovascular disease correlate with infiltration to adipose tissue of different immune cells, with uncertain influences on metabolism. Rats were fed a diet high in carbohydrates and saturated fats to develop diet-induced obesity over 16 weeks. This nutritional overload caused overexpression and secretion of phospholipase A(2) group IIA (pla2g2a) from immune cells in adipose tissue rather than adipocytes, whereas expression of adipose-specific phospholipase A(2) (pla2g16) was unchanged. These immune cells produce prostaglandin E(2) (PGE(2)), which influences adipocyte signaling. We found that a selective inhibitor of human pla2g2a (5-(4-benzyloxyphenyl)-(4S)-(p..

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University of Melbourne Researchers

Grants

Awarded by Australian Research Council


Awarded by Federation Fellowship


Awarded by National Health and Medical Research Council


Awarded by Senior Principal Research Fellowship


Funding Acknowledgements

The authors thank the Australia & New Zealand (ANZ) Trustee's Medical Research in Queensland for providing financial assistance via a PhD scholarship to A.I. and the Institute for Molecular Bioscience and The University of Queensland for a PhD scholarship to J.L. The authors also thank the Australian Research Council for funding (Grant DP1093245) and a Federation Fellowship (FF0668733) to D.P.F., the National Health and Medical Research Council (Grant 631534) for funding the research, and a Senior Principal Research Fellowship (APP1027369) to D.P.F.