Journal article

Leptin and the risk of Barrett's oesophagus

BJ Kendall, GA Macdonald, NK Hayward, JB Prins, I Brown, N Walker, N Pandeya, AC Green, PM Webb, DC Whiteman

GUT | BMJ PUBLISHING GROUP | Published : 2008

Abstract

BACKGROUND: Obesity is associated with increased risks of Barrett's oesophagus and oesophageal adenocarcinoma. Alterations in serum leptin and adiponectin, obesity-related cytokines, have been linked with several cancers and have been postulated as potential mediators of obesity-related carcinogenesis; however, the relationship with Barrett's oesophagus remains unexplored. METHODS: Serum leptin and adiponectin concentrations were measured on two subsets of participants within a case-control study conducted in Brisbane, Australia. Cases were people aged 18-79 years with histologically confirmed Barrett's oesophagus newly diagnosed between 2003 and 2006. Population controls, frequency matched ..

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University of Melbourne Researchers