Journal article

Free fatty acids are associated with obesity, insulin resistance, and atherosclerosis in renal transplant recipients

KA Armstrong, B Hiremagalur, BA Haluska, SB Campbell, CM Hawley, L Marks, J Prins, DW Johnson, NM Isbel

TRANSPLANTATION | LIPPINCOTT WILLIAMS & WILKINS | Published : 2005

Abstract

BACKGROUND: Insulin resistance (IR) may be implicated in the pathogenesis of atherosclerosis in renal transplant recipients (RTRs) and be contributed to, in part, by free fatty acids (FFAs), produced in excess in centrally obese individuals. The aim of this study was to determine the prevalence of IR and the relationships between FFAs, central obesity, and atherosclerosis in a cohort of prevalent RTRs. METHODS: Observational data were collected on 85 RTRs (mean age 54 years; 49% male, 87% Caucasian). Fasting serum was analyzed for FFAs, glucose, and insulin; IR was calculated using the homeostasis model assessment (HOMA-IR) score. Vascular structure was assessed by carotid intima-media thick..

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University of Melbourne Researchers