Journal article
Application of an exercise intervention on the evolution of diastolic dysfunction in patients with diabetes mellitus efficacy and effectiveness
JL Hare, MD Hordern, R Leano, T Stanton, JB Prins, TH Marwick
Circulation Heart Failure | LIPPINCOTT WILLIAMS & WILKINS | Published : 2011
Open access
Abstract
Background-Diastolic dysfunction (DD) is associated with adverse cardiovascular outcomes. We studied the impact of an exercise-based lifestyle intervention on the evolution of DD in patients with type 2 diabetes mellitus (T2DM) and prospectively investigated the clinical correlates of DD progression. Methods and Results-A total of 223 outpatients with T2DM were randomized to supervised exercise-based lifestyle intervention (initial gym-based program and lifestyle and diet advice followed by telephone-guided supervision) or usual care. Patients underwent echocardiographic assessment of diastolic function and metabolic and clinical evaluation at baseline and 3 years. Changes in prevalence and ..
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Awarded by National Health and Medical Research Council (NHMRC), Canberra, Australia
Awarded by National Heart Foundation of Australia
Awarded by NHMRC of Australia
Funding Acknowledgements
This study was supported in part by a Centre of Clinical Research Excellence award (455832) from the National Health and Medical Research Council (NHMRC), Canberra, Australia. Dr Hare was supported by a scholarship cofunded by the National Heart Foundation of Australia (PC 07B 3407) and the NHMRC of Australia (511266).Dr Marwick has received research support from the following companies: GE Medical Systems, Siemens, and Philips.