Journal article

Effects of exercise intervention on myocardial function in type 2 diabetes

MD Hordern, JS Coombes, LM Cooney, L Jeffriess, JB Prins, TH Marwick



OBJECTIVE: To identify the effects of a 1-year exercise intervention on myocardial dysfunction in patients with type 2 diabetes mellitus (T2DM). DESIGN: Randomised controlled trial, the Diabetes Lifestyle Intervention Study. SETTING: University hospital. PATIENTS: 223 T2DM patients without occult coronary artery disease, aged 18-75 were randomised to an exercise training group (n = 111) or a usual care group (n = 112). Complete follow-up data were available in 176 (88 exercise, 88 usual care). INTERVENTIONS: Exercise training consisted of gym, followed by telephone-monitored home-based exercise training. MAIN OUTCOME MEASURES: Tissue Doppler-derived myocardial velocities, strain-rate and str..

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Funding Acknowledgements

Supported in part by a Clinical Centre of Research Excellence Award from the National Health and Medical Research Council, Canberra, Australia. JSC had an NHMRC CCRE grant for >=$A10 000; JBP, NHMRC CCRE and Partnership grants for >=$A10 000; THM, NHMRC CCRE and Partnership grant for >=$A10 000; other research support: GE Medical imaging, >=$A10 000; NHMRC, National Health and Medical Research Council; CCRE, Centres for Clinical Research Excellence.