Journal article

Potentiation of glucose uptake, in 3T3-L1 adipocytes by PPAR gamma agonists is maintained in cells expressing a PPAR gamma dominant-negative mutant: Evidence for selectivity in the downstream responses to PPAR gamma activation

C Nugent, JB Prins, JP Whitehead, D Savage, JM Wentworth, VK Chatterjee, S O'Rahilly

MOLECULAR ENDOCRINOLOGY | OXFORD UNIV PRESS INC | Published : 2001

Abstract

Pharmacological agonists for the nuclear receptor PPAR gamma enhance glucose disposal in a variety of insulin-resistant states in humans and animals. The precise mechanisms whereby activation of PPAR gamma leads to increased glucose uptake in metabolically active cells remain to be determined. Notably, certain novel, synthetic PPAR gamma ligands appear to antagonize thiazolidinedione-induced adipogenesis yet stimulate cellular glucose uptake. We have explored the molecular mechanisms underlying the enhancement of glucose uptake produced by PPAR gamma agonists in 3T3-L1 adipocytes. Rosiglitazone treatment for 48 h significantly increased basal and insulin-stimulated glucose uptake and markedl..

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