Journal article

Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation

M Adams, CT Montague, JB Prins, JC Holder, SA Smith, L Sanders, JE Digby, CP Sewter, MA Lazar, VKK Chatterjee, S O'Rahilly

JOURNAL OF CLINICAL INVESTIGATION | ROCKEFELLER UNIV PRESS | Published : 1997

Abstract

Activation of peroxisome proliferator-activated receptor (PPAR) gamma, a nuclear receptor highly expressed in adipocytes, induces the differentiation of murine preadipocyte cell lines. Recently, thiazolidinediones (TZDs), a novel class of insulin-sensitizing compounds effective in the treatment of non-insulin-dependent diabetes mellitus (NIDDM) have been shown to bind to PPARgamma with high affinity. We have examined the effects of these compounds on the differentiation of human preadipocytes derived from subcutaneous (SC) and omental (Om) fat. Assessed by lipid accumulation, glycerol 3-phosphate dehydrogenase activity, and mRNA levels, subcultured preadipocytes isolated from either SC or Om..

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University of Melbourne Researchers