The role of 25-hydroxyvitamin D deficiency in promoting insulin resistance and inflammation in patients with Chronic Kidney Disease: a randomised controlled trial
William G Petchey, Ingrid J Hickman, Emma Duncan, Johannes B Prins, Carmel M Hawley, David W Johnson, Katherine Barraclough, Nicole M Isbel
BMC NEPHROLOGY | BMC | Published : 2009
BACKGROUND: Approximately 50% of patients with stage 3 Chronic Kidney Disease are 25-hydroxyvitamin D insufficient, and this prevalence increases with falling glomerular filtration rate. Vitamin D is now recognised as having pleiotropic roles beyond bone and mineral homeostasis, with the vitamin D receptor and metabolising machinery identified in multiple tissues. Worryingly, recent observational data has highlighted an association between hypovitaminosis D and increased cardiovascular mortality, possibly mediated via vitamin D effects on insulin resistance and inflammation. The main hypothesis of this study is that oral Vitamin D supplementation will ameliorate insulin resistance in patient..View full abstract
The authors would like to acknowledge the assistance of all the staff of the Nephrology outpatient department at Princess Alexandra Hospital for helping with recruitment, Dr Liza Phillips for assistance with the NF kappa B laboratory techniques, Diane Leary as study coordinator and to both the Princess Alexandra Hospital Foundation Trust and Roche for their financial support. WP also gratefully acknowledges both the CCRE and Department of Nephrology at the University of Queensland for their scholarship and resource support.