Journal article

Changes in serum adiponectin concentrations in critical illness: a preliminary investigation

Bala Venkatesh, Ingrid Hickman, Janelle Nisbet, Jeremy Cohen, John Prins

Critical Care (UK) | BIOMED CENTRAL LTD | Published : 2009

Abstract

INTRODUCTION: Adiponectin plays an important role in the regulation of tissue inflammation and insulin sensitivity. Perturbations in adiponectin concentration have been associated with obesity and the metabolic syndrome. Data on adiponectin pathophysiology in critical illness are limited. METHODS: Twenty three critically ill patients (9 severe sepsis, 7 burns, 7 trauma). Adiponectin assays on Days 3 (D3) and 7 (D7). Simultaneous, cortisol, cortisone and CRP measurements. Data from 16 historical controls were used for comparison. RESULTS: The mean plasma adiponectin concentration for the ICU cohort on D3 and D7 were not significantly different (4.1 +/- 1.8 and 5.0 +/- 3.3 mcg/ml respectively,..

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University of Melbourne Researchers