Journal article

Metabolic syndrome in severe chronic kidney disease: Prevalence, predictors, prognostic significance and effects of risk factor modification

David W Johnson, Kirsten Armstrong, Scott B Campbell, David W Mudge, Carmel M Hawley, Jeff S Coombes, Johannes B Prins, Nicole M Isbel

NEPHROLOGY | WILEY | Published : 2007


BACKGROUND: Metabolic syndrome (MS) is a significant risk factor for cardiovascular disease, mortality and chronic kidney disease (CKD) in the general population. However, the prevalence, predictors, prognostic value and treatment of MS in the CKD population have not been rigorously studied. METHODS: The study involved 200 stages 4 and 5 CKD patients enrolled in a randomized controlled trial of intensive multiple risk factor modification (targeting hypercholesterolaemia, hyperhomocysteinaemia, anaemia and disordered bone mineral metabolism) versus usual care. Participants were followed for a median period of 22 months. RESULTS: The overall prevalence of MS was 30.5%. MS was independently pre..

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University of Melbourne Researchers