Journal article

Fibroblast growth factor 1 - A key regulator of human adipogenesis

L Hutley, W Shurety, F Newell, R McGeary, N Pelton, J Grant, A Herington, D Cameron, J Whitehead, J Prins

DIABETES | AMER DIABETES ASSOC | Published : 2004

Abstract

Obesity, with its related problems, is recognized as the fastest growing disease epidemic facing the world, yet we still have limited insight into the regulation of adipose tissue mass in humans. We have previously shown that adipose-derived microvascular endothelial cells (MVECs) secrete a factor(s) that increases proliferation of human preadipocytes. We now demonstrate that coculture of human preadipocytes with MVECs significantly increases preadipocyte differentiation, evidenced by dramatically increased triacylglycerol accumulation and glycerol-3-phosphate dehydrogenase activity compared with controls. Subsequent analysis identified fibroblast growth factor (FGF)-1 as an adipogenic facto..

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University of Melbourne Researchers