Journal article

Diabetes screen during tuberculosis contact investigations highlights opportunity for new diabetes diagnosis and reveals metabolic differences between ethnic groups

Blanca Restrepo, Leanie Kleynhans, Alejandra B Salinas, Bassent Abdelbary, Happy Tshivhula, Genesis P Aguillon-Duran, Carine Kunsevi-Kilola, Gloria Salinas, Kim Stanley, Stephanus T Malherbe, Elizna Maasdorp, Moncerrato Garcia-Viveros, Ilze Louw, Esperanza M Garcia-Oropesa, Juan Carlos Lopez-Alvarenga, John B Prins, Gerhard Walzl, Larry S Schlesinger, Katharina Ronacher

TUBERCULOSIS | CHURCHILL LIVINGSTONE | Published : 2018

Abstract

Type 2 diabetes (T2D) is a prevalent risk factor for tuberculosis (TB), but most studies on TB-T2D have focused on TB patients, been limited to one community, and shown a variable impact of T2D on TB risk or treatment outcomes. We conducted a cross-sectional assessment of sociodemographic and metabolic factors in adult TB contacts with T2D (versus no T2D), from the Texas-Mexico border to study Hispanics, and in Cape Town to study South African Coloured ethnicities. The prevalence of T2D was 30.2% in Texas-Mexico and 17.4% in South Africa, with new diagnosis in 34.4% and 43.9%, respectively. Contacts with T2D differed between ethnicities, with higher smoking, hormonal contraceptive use and ch..

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University of Melbourne Researchers

Grants

Awarded by South African Medical Research Council under the US-South African Program for Collaborative Biomedical Research


Awarded by National Research Foundation of South Africa


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Funding Acknowledgements

This work was supported by the National Institutes of Health, National Institute of Allergy and Infectious Diseases (NIAID) and the South African Medical Research Council under the US-South African Program for Collaborative Biomedical Research [grant number R01AI116039], to KR and BIR. The content is solely the responsibility of the authors and does not necessarily represent the official views of the South African Medical Research Council. Grant number is RDYR14072278217 by "The National Research Foundation of South Africa" was awarded to KR.