Journal article

N-acetylcysteine add-on treatment leads to an improvement of fornix white matter integrity in early psychosis: a double-blind randomized placebo-controlled trial.

Paul Klauser, Lijing Xin, Margot Fournier, Alessandra Griffa, Martine Cleusix, Raoul Jenni, Michel Cuenod, Rolf Gruetter, Patric Hagmann, Philippe Conus, Philipp S Baumann, Kim Q Do

Transl Psychiatry | Published : 2018

Abstract

Mechanism-based treatments for schizophrenia are needed, and increasing evidence suggests that oxidative stress may be a target. Previous research has shown that N-acetylcysteine (NAC), an antioxidant and glutathione (GSH) precursor almost devoid of side effects, improved negative symptoms, decreased the side effects of antipsychotics, and improved mismatch negativity and local neural synchronization in chronic schizophrenia. In a recent double-blind randomized placebo-controlled trial by Conus et al., early psychosis patients received NAC add-on therapy (2700 mg/day) for 6 months. Compared with placebo-treated controls, NAC patients showed significant improvements in neurocognition (process..

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