Changes in levels of cortical metabotropic glutamate 2 receptors with gender and suicide but not psychiatric diagnoses

Abstract

BACKGROUND: We previously reported that, compared to controls, there are lower levels of [3H]LY341495 binding to metabotropic 2/3 receptors (GRM2/3) in Brodmann's area (BA) 24, but not 17 or 46, from subjects with major depressive disorders (MDD) but not bipolar disorders (BD) or schizophrenia. To be able to better interpret these data we have now measured levels of GRM2 in two of these cortical regions. METHODS: Using a rabbit anti-metabotropic GRM2 monoclonal antibody with Western blotting we measured levels of GRM2 in BA 24 and 46 from subjects with MDD, BD, schizophrenia and controls (n = 15 per group). RESULTS: Compared to controls, levels of GRM2, normalised to β-actin, did not differ ..