Journal article
Development and Characterization of a Sucrose Microneedle Neural Electrode Delivery System
NV Apollo, J Jiang, W Cheung, S Baquier, A Lai, A Mirebedini, J Foroughi, GG Wallace, MN Shivdasani, S Prawer, S Chen, R Williams, MJ Cook, DAX Nayagam, DJ Garrett
Advanced Biosystems | WILEY-V C H VERLAG GMBH | Published : 2018
Abstract
Stable brain–machine interfaces present extraordinary therapeutic and scientific promise. However, the electrode–tissue interface is susceptible to instability and damage during long-term implantation. Soft, flexible electrodes demonstrate improved longevity, but pose a new challenge with regard to simple and accurate surgical implantation. A high aspect ratio water-soluble microneedle is developed based on sucrose which permits straightforward surgical implantation of soft, flexible microelectrodes. Here, a description of the microneedle manufacturing process is presented, along with in vitro and in vivo safety and efficacy assessments. Successful fabrication requires control of the glass t..
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Awarded by DECRA
Funding Acknowledgements
The authors thank Ceara McGowan for help with histological processing and immunohistochemistry and Thomas Spencer for surgical assistance. Australian National Fabrication Facility (Materials Node) are acknowledged for access to fabrication facilities. This work was supported by the MMI-CSIRO materials science scholarship for N.V.A. N.V.A. and D.J.G. were supported by an NHMRC Project Grant. J.F. was supported by a DECRA fellowship (DE12010517). The Bionics Institute acknowledges the Victoria State Government for Operational Infrastructure Funding. The manuscript was written through contributions of all authors. All authors have given approval to the final version of the manuscript.